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INTERMEDIATE LEVEL

Tell us about a time when you had to troubleshoot and resolve technical issues in the laboratory.

Virologist Interview Questions
Tell us about a time when you had to troubleshoot and resolve technical issues in the laboratory.

Sample answer to the question

In my previous role as a Virology Research Assistant, I encountered a technical issue in the laboratory while conducting viral assays. The instrument we were using for qPCR analysis suddenly stopped working and we were unable to get any results. To troubleshoot the issue, I carefully inspected the instrument, checking for any loose connections or errors in the software. I discovered that a cable was not properly connected, causing the instrument to malfunction. I quickly reconnected the cable and restarted the instrument, which resolved the issue. As a result, we were able to continue with our analysis and obtain the necessary data for our research project.

A more solid answer

During my time as a Virology Research Assistant, I encountered a challenging technical issue while performing viral assays using PCR. The instrument we were using suddenly displayed an error message and stopped working, hindering our progress in the research project. To troubleshoot the issue, I first reviewed the instrument's user manual and consulted with my colleagues to gather insights. Working systematically, I inspected the instrument for any visible physical damages and checked the connections to ensure they were secure. After thorough examination, I identified that the issue was due to a malfunctioning thermocycler module. To resolve the problem, I promptly contacted the manufacturer's technical support, providing them with detailed information about the error message and our troubleshooting steps. With their guidance, I carefully replaced the faulty module, testing it to ensure proper functionality. As a result, we were able to resume the experiments and successfully obtain the required data for our research project.

Why this is a more solid answer:

The solid answer provides more specific details about the technical issue faced in the laboratory and demonstrates the candidate's analytical and critical thinking abilities. They showcase their proficiency with PCR and their ability to resolve the issue by following a systematic troubleshooting approach and seeking assistance from the manufacturer's technical support. However, the answer could further enhance by including more information on the impact of resolving the issue and any additional measures taken to prevent similar problems in the future.

An exceptional answer

In my role as a Virology Research Assistant, I encountered a complex technical issue during the execution of viral assays utilizing PCR techniques. The research project focused on investigating the viral load in patient samples, and it was crucial to obtain accurate results. During one experiment, the PCR machine suddenly shut down, resulting in an unexpected system error. Recognizing the urgency of the situation, I immediately performed an initial assessment of the instrument, checking for any visible signs of malfunctioning components and inspecting the power supply. After ruling out external factors, I narrowed down the problem to an internal thermocycler malfunction. To resolve the issue, I carefully disassembled the thermocycler section and performed a comprehensive inspection, noticing a damaged heating element. Determined to find a quick solution, I reached out to a nearby research institution, requesting the temporary use of their PCR machine to complete the experiment. Simultaneously, I contacted the manufacturer's technical support team to order a replacement heating element. While waiting for the replacement part to arrive, I performed troubleshooting on other sections of the PCR machine, ensuring optimal functionality. Once the new heating element arrived, I successfully installed it, meticulously following the manufacturer's instructions. As a result of my proactive troubleshooting and collaboration with external resources, we successfully obtained accurate and reliable data, contributing significantly to the research project's progression.

Why this is an exceptional answer:

The exceptional answer provides a detailed and comprehensive account of the technical issue faced in the laboratory, showcasing the candidate's strong analytical skills, critical thinking abilities, and determination to find a solution. They demonstrate resourcefulness by seeking assistance from a nearby research institution and proactively troubleshooting other sections of the PCR machine while waiting for the replacement part. The answer also highlights the impact of their actions on the research project's progression and emphasizes their commitment to delivering accurate and reliable data. To further improve, the candidate could include information on any preventive measures implemented to minimize the likelihood of similar issues in the future.

How to prepare for this question

  • Familiarize yourself with common technical issues that can arise in laboratory settings, especially those related to PCR and viral assays.
  • Review troubleshooting procedures for laboratory instruments and equipment.
  • Stay updated on the latest advancements in laboratory technology to understand potential challenges and solutions.
  • Develop problem-solving skills by practicing systematic thinking and approaching issues from multiple angles.
  • Enhance your knowledge of aseptic techniques and handling infectious agents to minimize contamination-related issues.

What interviewers are evaluating

  • Troubleshooting technical issues
  • Critical thinking
  • Experience with PCR and viral assays

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