Can you provide an example of a challenging problem you encountered in the laboratory and how you solved it?

JUNIOR LEVEL
Can you provide an example of a challenging problem you encountered in the laboratory and how you solved it?
Sample answer to the question:
Yes, I can provide an example of a challenging problem I encountered in the laboratory. One time, I was tasked with conducting a series of tests on a sample to determine its composition. However, the sample was contaminated, which made it difficult to obtain accurate results. To solve this problem, I carefully reviewed the test procedures and identified potential sources of contamination. I implemented stricter safety measures and made sure to use sterile materials throughout the process. Additionally, I consulted with senior scientists and collaborated with my colleagues to brainstorm possible solutions. As a result, we were able to successfully isolate and analyze the sample, obtaining reliable data for further analysis.
Here is a more solid answer:
Certainly! I'd like to share an example of a challenging problem I encountered in the laboratory. During a project, I was responsible for performing a DNA extraction from a particular sample. However, I encountered difficulty in obtaining a satisfactory yield from the sample. To address this issue, I conducted a thorough review of the DNA extraction protocol and identified potential areas for improvement. I adjusted several parameters, such as the incubation time and temperature, as well as the concentration of reagents used. Additionally, I sought guidance from senior scientists and collaborated with my colleagues to brainstorm alternative techniques and troubleshoot the problem. Through these efforts, I was able to optimize the DNA extraction process and achieve a higher yield, which greatly contributed to the success of the project.
Why is this a more solid answer?
The solid answer provides a more detailed account of the challenging problem in the laboratory and the candidate's approach to solving it. It demonstrates their analytical thinking skills by thoroughly reviewing the protocol and making necessary adjustments. Furthermore, it showcases their attention to detail and ability to work effectively in a team by seeking guidance from senior scientists and collaborating with colleagues. However, it can still be improved by including specific outcomes or results of the optimized process.
An example of a exceptional answer:
Absolutely! Let me share an exceptional example of a challenging problem I encountered in the laboratory. During a study on drug interactions, I was tasked with analyzing the effects of a particular drug combination on cancer cells. However, I faced a significant roadblock when the cancer cells did not respond as expected to the treatment. To overcome this challenge, I meticulously examined the experimental design and conducted in-depth research on potential factors affecting drug efficacy. Through this analysis, I identified a potential interaction between the drug combination and the culture medium used for cell growth. To validate this hypothesis, I designed a series of control experiments using different culture media. The results confirmed that the standard culture medium was interfering with the drug response. I immediately relayed this information to my team, and together we optimized the culture conditions to achieve accurate and reproducible results. As a result of our efforts, we were able to successfully demonstrate the efficacy of the drug combination and published our findings in a reputable scientific journal.
Why is this an exceptional answer?
The exceptional answer provides a highly detailed and comprehensive account of a challenging problem in the laboratory and the candidate's exceptional problem-solving abilities. It showcases their ability to critically analyze data, conduct thorough research, and identify potential factors influencing the experimental outcome. Additionally, it highlights their strong communication and collaboration skills by effectively relaying information to the team. The answer also demonstrates the candidate's enthusiasm and commitment to contributing to medical research and clinical health, as mentioned in the job description. A further improvement would be to incorporate details about the impact or significance of the published findings.
How to prepare for this question:
  • Review past laboratory experiences and identify challenging problems encountered.
  • Reflect on the steps taken to solve those problems and the outcomes achieved.
  • Brush up on laboratory protocols and techniques related to the job description.
  • Stay updated with recent advancements in the biomedical field.
  • Practice articulating problem-solving skills and teamwork experiences in a clear and concise manner during mock interviews.
What are interviewers evaluating with this question?
  • Analytical and critical thinking skills
  • Attention to detail and organization
  • Ability to work in a team and communicate effectively

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