Tell me about a time when you had to adapt your approach to a research project due to unexpected results. How did you handle the situation?
Synthetic Chemist Interview Questions
Sample answer to the question
During a research project on the synthesis of a specific compound, I encountered unexpected results that deviated from the expected reaction pathway. I had initially planned to use a specific reagent for a key step in the synthesis, but the reaction did not proceed as anticipated. To adapt my approach, I thoroughly reviewed the reaction mechanism and consulted with colleagues and experts in the field. Through these discussions, I identified a potential alternative reagent that could yield the desired product. I quickly adjusted my experimental setup and carried out the reaction with the new reagent. Thankfully, this modification led to successful synthesis, and I was able to obtain the expected compound. To handle the situation, I maintained detailed records of the unexpected results, the troubleshooting process, and the final successful synthesis. This experience taught me the importance of being adaptable in research and the value of collaboration and seeking advice when faced with unexpected challenges.
A more solid answer
During a research project on the synthesis of a specific compound, I encountered unexpected results that deviated from the expected reaction pathway. The planned reagent did not yield the desired product, prompting me to reevaluate the reaction mechanism and seek assistance from more experienced colleagues. Through collaborative discussions, we identified a potential alternative reagent with similar reactivity. I adjusted my experimental setup and performed the reaction with the new reagent. The synthesis was successful, and I obtained the desired compound. This experience taught me the importance of adaptability and problem-solving in research, as well as the value of collaboration and seeking advice from experts.
Why this is a more solid answer:
The solid answer expands on the basic answer by providing more details and examples. It highlights the candidate's adaptability and problem-solving skills by discussing the need to reconsider the reaction mechanism and explore alternative reagents. Additionally, it explicitly mentions collaboration and seeking assistance from experienced colleagues. However, the answer could still benefit from more specific details about the troubleshooting process and the candidate's contributions to the collaborative discussions.
An exceptional answer
During a research project on the synthesis of a specific compound, I encountered unexpected results that deviated from the expected reaction pathway. The planned reagent failed to produce the desired product, indicating a need to reassess my approach. To address this, I thoroughly analyzed the reaction data and consulted with experts in the field. We identified potential reasons for the unexpected results, such as side reactions or impurities in the starting materials. To investigate further, I designed a series of control experiments and conducted additional analyses, including NMR and GC. These experiments helped pinpoint the issue and suggested a modification to the reaction conditions. I implemented the changes and successfully obtained the target compound. Throughout this process, I maintained detailed records of all observations, analyses, and modifications made to the original synthesis plan. This experience showcased not only my adaptability and problem-solving skills but also my ability to effectively analyze and interpret complex data, collaborate with experts, and document research findings.
Why this is an exceptional answer:
The exceptional answer goes above and beyond by providing even more specific details and examples. It highlights the candidate's analytical skills by discussing the thorough analysis of reaction data and the design of control experiments. It also demonstrates their ability to collaborate effectively by consulting with experts and leveraging their knowledge. Additionally, the answer emphasizes the candidate's organizational skills by mentioning the comprehensive record-keeping throughout the project. This answer fully addresses the evaluation areas and aligns with the job description's emphasis on strong analytical and critical thinking skills, as well as the ability to work collaboratively and manage multiple projects.
How to prepare for this question
- Familiarize yourself with the scientific method and problem-solving approaches in research.
- Reflect on past research projects or experiments where you encountered unexpected results and how you handled them.
- Study reaction mechanisms and become familiar with different reagents and their potential applications.
- Practice explaining your research process, including troubleshooting and collaboration, in a clear and concise manner.
- Review the importance of record-keeping and documentation in research.
What interviewers are evaluating
- Adaptability
- Problem-solving
- Collaboration
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