Structural Biologist
A structural biologist studies the molecular structure of biological macromolecules, seeking to understand the architecture and arrangements of atoms within them and how this affects their function in biological systems.
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Sample Job Descriptions for Structural Biologist
Below are the some sample job descriptions for the different experience levels, where you can find the summary of the role, required skills, qualifications, and responsibilities.
Junior (0-2 years of experience)
Summary of the Role
As a Junior Structural Biologist, you will be part of a team dedicated to understanding the three-dimensional structures of proteins, nucleic acids, and other biomolecules. This role involves the application of techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to discern the architecture of biological macromolecules and their implications in health and disease.
Required Skills
- Proficient in the use of biochemical and molecular biology laboratory techniques
- Experience with protein purification and characterization
- Knowledge of X-ray crystallography, NMR, or cryo-EM
- Strong analytical and problem-solving abilities
- Attention to detail and a commitment to producing high-quality work
Qualifications
- Bachelor's or Master's degree in Structural Biology, Biochemistry, Biophysics, or a related field
- Understanding of molecular biology techniques and principles
- Familiarity with structural biology software and data analysis
- Ability to work in a multidisciplinary team environment
- Strong communication skills for presenting findings and collaborating with research partners
Responsibilities
- Prepare biological samples for structural analysis
- Operate and maintain laboratory instruments such as X-ray diffractometers, NMR spectrometers, and cryo-EM equipment
- Analyze and interpret data from structural biology experiments
- Collaborate with cross-functional research teams
- Stay up-to-date with advancements in structural biology and related fields
- Document experimental procedures and results for technical reports and scientific publications
Intermediate (2-5 years of experience)
Summary of the Role
As a Structural Biologist with intermediate experience, you will contribute to the understanding of biomolecular structures and their functions. You will employ techniques such as X-ray crystallography, NMR spectroscopy, cryo-electron microscopy, and computational modeling to analyze proteins, nucleic acids, and other macromolecules. Your role will be crucial in elucidating the mechanisms of biological processes and in the development of new therapeutics.
Required Skills
- Proficiency in structural biology techniques and data analysis.
- Critical thinking and problem-solving abilities.
- Excellent written and verbal communication skills.
- Ability to work independently and as part of a team.
- Strong organizational skills and attention to detail.
- Proficiency with relevant software and data analysis tools.
Qualifications
- Master's degree or PhD in Structural Biology, Biochemistry, Biophysics, or related field.
- 2-5 years of post-graduate experience in a laboratory setting, with a focus on structural biology.
- Proven track record of successful structural determination of biomolecules.
- Experience with X-ray crystallography, NMR, or cryo-EM techniques.
- Strong understanding of protein chemistry and molecular biology.
- Experience with computational modeling and data analysis software.
Responsibilities
- Design and conduct experiments to determine the structures of biological macromolecules.
- Analyze data from structural biology experiments and prepare reports.
- Maintain and operate high-end experimental equipment such as X-ray diffractometers, NMR spectrometers, and electron microscopes.
- Collaborate with interdisciplinary teams, including chemists, biochemists, and computational biologists, to interpret results and propose new experimental directions.
- Stay current with advancements in structural biology techniques and apply them to ongoing research.
- Contribute to scientific manuscript preparation and grant writing.
- Mentor junior researchers and technicians in the laboratory.
Senior (5+ years of experience)
Summary of the Role
Seeking a seasoned Structural Biologist to lead our research team in understanding the architecture of complex biomolecules. The successful candidate will be responsible for employing a range of techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to determine the structures of proteins, nucleic acids, and other macromolecules to understand their function and role in health and disease.
Required Skills
- Expertise in molecular biology techniques and protein chemistry.
- Proficiency in data analysis software and structural modeling programs.
- Ability to work collaboratively in a multi-disciplinary team environment.
- Excellent communication and leadership skills.
- Strong grant writing and fundraising abilities.
Qualifications
- Ph.D. in Structural Biology, Biochemistry, Biophysics or a related field.
- Minimum of 5 years postdoctoral experience in structural biology or a related discipline.
- Proven track record of publications in the field of structural biology.
- Extensive experience with techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy.
- Strong analytical and problem-solving skills.
Responsibilities
- Design and conduct experiments to determine the three-dimensional structures of biological macromolecules.
- Analyze structural data to derive insights into molecular function and interactions.
- Collaborate with biochemists, biophysicists, and molecular biologists to integrate structural data with biochemical and genetic information.
- Develop and refine methodologies for structural determination, such as crystallization techniques and computational modeling.
- Publish findings in peer-reviewed journals and present at international conferences.
- Supervise and mentor junior scientists and research staff.
- Manage laboratory equipment, including maintenance and procurement of new technology.
- Seek out funding opportunities and write grant proposals to support research endeavors.
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