Can you share an example of a significant challenge you faced in a research project and how you overcame it?

Sample answer to the question

In my previous project as a research assistant, we were studying protein interactions relevant to cancer treatment. One major challenge was the repeatability of our experiments. Sometimes, the results were inconsistent, which was baffling. To tackle this, I first meticulously reviewed our experimental protocols. I realized that the temperature fluctuations in our lab could be a factor. So, I implemented a stricter monitoring process for environmental conditions during experiments. Over time, our results became more consistent, which was a huge relief and a step forward for the reliability of our research.

A more solid answer

In my role as a research associate, I encountered a major hurdle during a project on neurodegenerative diseases. Our data showed irregularities that put months of work at risk. I honed in on the issue by conducting a statistical analysis to identify patterns in the discrepancies. I then realized our software calibration was off. By collaborating with the IT team, I led the recalibration process, adjusting our protocols accordingly. It required reevaluating several weeks' worth of data, but ultimately it reinforced the robustness of our research and contributed to a successful publication.

Why this is a more solid answer:

The solid answer provides a clearer illustration of how the candidate used their critical thinking and analytical skills to identify and solve the research problem. It shows an application of statistical analysis and demonstrates the ability to collaborate with others to overcome challenges. The answer could still improve by detailing the time management strategies used during the recalibration and relying more on specific examples of adaptability, such as how the candidate adjusted to new software or methodology changes.

An exceptional answer

While researching novel compounds for type 2 diabetes, my team faced a baffling inconsistency in our trial results. Applying critical thinking, I hypothesized that our experimental design might be at fault. Delving into a thorough root-cause analysis, I scrutinized every step and found that our control group wasn't properly isolated from unintended variables, like ambient temperature. To solve this, I designed a new set of rigorous experimental protocols, employing real-time data monitoring technology for precise environmental control. I also strategically divided the workload and introduced agile methodology for better project management, keeping the team on a tight yet flexible schedule. This adaptability allowed us to not only salvage the project but also to refine our methodology, resulting in a robust set of data that upheld high scientific standards, ultimately leading to a groundbreaking publication.

Why this is an exceptional answer:

This exceptional answer goes beyond the problem-solving aspect by describing a detailed analytical process that led to the discovery of the issue. It demonstrates the candidate's high level of competence in critical thinking, experimental design, and adaptability. Mentioning the use of new technology and methodologies showcases flexibility. Additionally, the implementation of agile methodology highlights time management and organization skills. Furthermore, the candidate references the positive outcome of their efforts, supporting their track record of successful research outcomes.

How to prepare for this question

Reflect on past research projects and identify challenges that required the application of the job's key skills. Make a list of these situations so you can recall them easily during the interview.
Practice discussing technical aspects of your work in lay terms. Being able to translate complex ideas to a broader audience demonstrates strong communication skills, which are valued in a research environment.
Prepare examples of how you've shared your findings or contributed to discussions in the scientific community. This can illustrate your experience with scientific communication and presentations.
Quantify the outcomes of your problem-solving efforts when possible. Highlighting any metrics that show the impact or improvement your actions caused can make your answer more compelling.
Consider situations where you have implemented new techniques or adapted to changes. This will demonstrate your ability to learn and apply new technologies and methodologies, which is essential for the role.

What interviewers are evaluating

Critical thinking
Experimental design
Time management and organization
Adaptability to new technologies and methodologies